5-azaindazole compounds and methods of use

US9434725B2 · kind B2 · utility

Assignee

• F. Hoffmann-La Roche AG · CH

Inventors

• Steven Do · San Jose, US
• Huiyong Hu · Fremont, US
• Aleksandr Kolesnikov · Mill Valley, US
• Vickie Hsiao-Wei Tsui · Burlingame, US
• Xiaojing Wang · Foster City, US

Key dates

• Filing date: Jun 26, 2013
• Grant date: Sep 6, 2016
• Expiry date: Jul 12, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

5-Azaindazole compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.