7-oxo-thiazolopyridine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease

US9434745B2 · kind B2 · utility

Assignees

• Savira pharmaceuticals GmbH · AT
• F. Hoffmann-La Roche AG · CH
• European Molecular Biology Laboratory · DE

Inventors

• Andrea Wolkerstorfer · Wien, AT
• Oliver Szolar · Wien, AT
• Norbert Handler · Wien, AT
• Stephen Cusack · Seyssinet-Pariset, FR
• Thibault Sauvaitre · Frankfurt am Main, DE
• Céline Simon · Illkirch-Graffenstaden, FR
• Christophe Morice · Widensolen, FR
• Bruno Giethlen · Altorf, FR
• Thierry LANGER · Oberschaeffolsheim, FR
• Mark Smith · Saffron Walden, GB
• Sung-Sau So · Verona, US
• Dirk CLASSEN-HOUBEN · Brixlegg, AT
• Helmut Buschmann · Walheim, DE

Key dates

• Filing date: May 23, 2013
• Grant date: Sep 6, 2016
• Expiry date: May 23, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound having the general formula (A), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof,which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.