Derivatives of pyridinone as inhibitors for tissue transglutaminase

US9434763B2 · kind B2 · utility

Assignee

• Zedira GmbH · DE

Inventors

• Christian Büchold · Karben, DE
• Uwe Gerlach · Hattersheim, DE
• Martin Hils · Darmstadt, DE
• Ralf Pasternack · Griesheim, DE
• Johannes Weber · Stuttgart, DE

Key dates

• Filing date: Jul 12, 2013
• Grant date: Sep 6, 2016
• Expiry date: Jul 12, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/1024
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to pyridinone derivatives of general formula (I) as inhibitors of tissue transglutaminase, to methods for producing the pyridinone derivatives, to pharmaceutical compositions containing said pyridinone derivatives and to their use for the prophylaxis and treatment of diseases associated with tissue transglutaminase.