Small molecule inhibitors of Dusp6 and uses therefor

US9439877B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Billy W. Day · Pittsburgh, US
• Waikok Michael Tsang · Pittsburgh, US
• Vasiliy N. Korotchenko · Rockville, US

Key dates

• Filing date: Jul 9, 2015
• Grant date: Sep 13, 2016
• Expiry date: Jul 9, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.