Amine-containing lipidoids and uses thereof

US9439968B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Daniel Griffith Anderson · Framingham, US
• Kathryn Ann Whitehead · Pittsburgh, US
• Joseph R. Dorkin · Somerville, US
• Arturo Jose Vegas · Belmont, US
• Yunlong Zhang · North Haven, US
• Robert S. Langer · Newton, US

Key dates

• Filing date: Jan 4, 2016
• Grant date: Sep 13, 2016
• Expiry date: Jan 4, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.