Substituted chroman-6-yloxy-cycloalkanes and their use as pharmaceuticals

US9440941B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Werngard Czechtizky · Frankfurt, DE
• John Weston · Frankfurt am Main, DE
• Nils RACKELMANN · Frankfurt am Main, DE
• Volker Kraft · Frankfurt am Main, DE
• Petra Arndt · Frankfurt am Main, DE
• Klaus Wirth · Frankfurt am Main, DE
• Heinz GOEGELEIN · Frankfurt, DE
• Olaf Ritzeler · Bad Soden, DE

Key dates

• Filing date: Mar 7, 2014
• Grant date: Sep 13, 2016
• Expiry date: Mar 7, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65522
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted chroman-6-yloxy-cycloalkanes of the formula (I) in which Ar, R1 to R4, p and q are as defined in the claims. The compounds of the formula (I) are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.