Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use

US9440948B2 · kind B2 · utility

Assignees

• University of Florida Research Foundation, INC. · US
• The Trustees of the University of Pennsylvania · US

Inventors

• William R. Kem · Gainesville, US
• Ferenc Soti · Gainesville, US
• Anne Rouchaud · Brussels, BE
• Hong Xing · Gainesville, US
• Jon M. Lindstrom · Stockholm, SE
• Kristin Marie Andrud · Lakewood, US

Key dates

• Filing date: Sep 2, 2011
• Grant date: Sep 13, 2016
• Expiry date: Oct 16, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Embodiments of the present disclosure provide for compounds such as those shown in FIG. 1.1 (compounds A, B, C, and D), 2′substituted nicotine compounds, azetidine compounds, ether linked nicotine compounds (FIG. 1.2, compounds E, F, G, and H), methods of synthesis of the compounds, methods of treatment of a condition using compounds A, B, C, D, 2′substituted nicotine compounds, azetidine compounds, or ether linked nicotine compounds, methods of selectively stimulating alpha7 nAChR and/or alpha4beta2 receptors, and the like.