Pyrrolo[2, 1-F] [1,2,4]triazine derivative and use thereof for treating tumors

US9440981B2 · kind B2 · utility

Assignee

• PHARMABLOCK (NANJING) R&D CO. LTD · CN

Inventors

• Xihan Wu · Shanghai, CN
• Minmin Yang · Nanjing, CN
• Qingning Shu · 安丰镇, CN
• Chunrui Zhu · 安丰镇, CN

Key dates

• Filing date: May 17, 2013
• Grant date: Sep 13, 2016
• Expiry date: Jun 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a pyrrolo[2,1-f][1,2,4]triazine derivative of Formula (I) and use thereof for treating tumors. The compound has remarkable antiproliferative activity for a variety of human tumor cell lines, and is useful for treating cancers, especially solid tumors such as gastric cancer, lung cancer, liver cancer, breast cancer, colon cancer, prostatic cancer, and oral cancer.