Patent · US Active

Small molecule inhibitors of TRPA1

US9440993B2 · kind B2 · utility

0Cited by

2References

29Claims

0Family size

Assignee

B.R.A.I.N. Biotechnology Research and Information Network AG · DE

Inventors

Michael Krohn · Lorsch, DE
Dirk Sombroek · Darmstadt, DE

Key dates

Filing date	May 11, 2012
Grant date	Sep 13, 2016
Priority date	—
Expiry date	Jan 2, 2033

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2800/782
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.