Patent · US Active

Small molecule modulators of pRb inactivation

US9447060B2 · kind B2 · utility

0Cited by

0References

13Claims

0Family size

Assignee

The Wistar Institute of Anatomy and Biology · US

Inventors

Ronen Marmorstein · Swarthmore, US
Daniela Fera · Cambridge, US

Key dates

Filing date	Nov 6, 2012
Grant date	Sep 20, 2016
Priority date	—
Expiry date	Nov 6, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D285/08
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a small molecule treatment of diseases/conditions caused by a virus carrying a viral oncoprotein. In one embodiment, the virus which carries the viral oncoprotein is HPV. The small molecule useful herein includes thiadiazolin-3,5-dione compounds having an optionally substituted aryl group bound to one nitrogen atom of said thiadiazolin-3,5-dione compound. The small molecules may also be administered with a compound which inhibits binding of HPV E6 to p53. In one embodiment, the thiadiazolin-3,5-dione compound has formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R1 and R2 are defined herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.