Peptides and methods of use

US9447147B2 · kind B2 · utility

Assignee

• Baxalta Incorporated · CH

Inventors

• Michael Dockal · Wien, AT
• Thomas Polakowski · Berlin, DE
• Frank Osterkamp · Berlin, DE
• Rudolf Hartmann · Bisamberg, AT
• Matthias Paschke · Berlin, DE
• Bettina Hartlieb · Wien, AT
• Friedrich Scheiflinger · Wien, AT

Key dates

• Filing date: Feb 27, 2015
• Grant date: Sep 20, 2016
• Expiry date: Feb 27, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/745
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides peptides, including peptides that bind and, optionally, inhibit Protein S, and compositions thereof. The peptides may be used to, e.g., inhibit Protein S activity, enhance thrombin formation in a subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify Protein S, and identify a Protein S binding compound.