Base-detecting pore
US9447152B2 · kind B2 · utility
62Cited by
15References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 6, 2009 |
| Grant date | Sep 20, 2016 |
| Priority date | — |
| Expiry date | Jan 9, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6869
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a mutant α-hemolysin (α-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing. The pore is particularly useful for sequencing DNA or RNA. A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore. The pore is specifically modified to facilitate positioning of the adaptor and may be modified to facilitate covalent attachment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.