Antibodies to phosphorylated tau aggregates

US9447179B2 · kind B2 · utility

Assignees

• KATHOLIEKE UNIVERSITEIT LEUVEN, KU RESEARCH & DEVELOPMENT · BE
• FUJIREBIO EUROPE N.V. · BE

Inventors

• Joris Winderickx · Wilsele, BE
• Eugeen Vanmechelen · Zevergem, BE
• Fred Van Leuven · Leuven, BE

Key dates

• Filing date: Jul 16, 2012
• Grant date: Sep 20, 2016
• Expiry date: Jul 16, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/565
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention concerns affinity tools for oligomeric forms of tau protein. It relates to the field of neurodegeneration, more particularly to the field of tau-related diseases and tauopathy. The invention provides novel tau antibodies and antibody fragments, nucleic acids encoding such antibodies and antibody fragments, cell lines producing such antibodies and antibody fragments, antibody compositions, and kits for the detection of aggregated tau and for the diagnosis of diseases involving aggregated tau. The invention further provides methods for the detection of aggregated tau, for the diagnosis of diseases involving aggregated tau, and for the identification of compositions interfering with the formation and/or stability of tau aggregates.