Bispecific chimeric antigen receptors and encoding polynucleotides thereof
US9447194B2 · kind B2 · utility
70Cited by
2References
28Claims
0Family size
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Inventor
Key dates
| Filing date | Feb 13, 2013 |
| Grant date | Sep 20, 2016 |
| Priority date | — |
| Expiry date | Feb 13, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.