Pharmaceutical compositions comprising silica microspheres

US9452137B2 · kind B2 · utility

Assignee

• PERRIGO ISRAEL PHARMACEUTICALS LTD. · IL

Inventors

• Marina Shevachman · Beer Sheva, IL
• Amira Ze' Evi · Omer, IL
• Eilon Asculai · Rahat, IL
• Batella Binyaminovich · Beer Sheva, IL
• Nir Avram · Meitar, IL

Key dates

• Filing date: Nov 24, 2014
• Grant date: Sep 27, 2016
• Expiry date: Nov 24, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A topical composition which includes a silica microspheres and an active ingredient in the amount of 0.01 to 15.0% w/w wherein the active ingredient is selected from adapalene, an antibiotic, tazarotene, tretinoin, a retinoid, or any combination thereof. The topical composition may also include benzoyl peroxide as an active ingredient. The topical compositions provide sustained release of the active ingredient so as to reduce skin irritation.