Delivery of biologic therapeutics

US9452138B2 · kind B2 · utility

Assignee

• Abbott Cardiovascular Systems, Inc. · US

Inventors

• Mikael Trollsas · San Jose, US
• John Stankus · Plano, US
• James Su · Newark, US
• Syed F. A. Hossainy · Fremont, US
• Joshua Takeshi Smith · Campbell, US
• Shadid Askar · Round Rock, US

Key dates

• Filing date: Dec 27, 2013
• Grant date: Sep 27, 2016
• Expiry date: Dec 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/21
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.