Influenza virus vaccines and uses thereof
US9452211B2 · kind B2 · utility
25Cited by
1References
13Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 27, 2012 |
| Grant date | Sep 27, 2016 |
| Priority date | — |
| Expiry date | Nov 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16171
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.