Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof

US9452995B2 · kind B2 · utility

Assignee

• Jikai Biosciences, Inc. · CN

Inventor

• Yu Ge · Shanghai, CN

Key dates

• Filing date: Jun 22, 2015
• Grant date: Sep 27, 2016
• Expiry date: Jun 22, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

PIM kinase inhibitor compound having a structure as represented by Formula I, and isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts thereof. The compounds significantly inhibit the Pim kinase activity and are used to prepare drugs to treat PIM kinase mediated diseases, such as cancers, multi drug resistance, and inflammatory bowel disease. Also provided are methods for preparing and using the compounds represented by Formula I.