Patent · US Active

Piperidine and piperazine derivatives as autotaxin inhibitors

US9452997B2 · kind B2 · utility

4Cited by

10References

17Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Kai Schiemann · Darmstadt, DE
Melanie Schultz · Darmstadt, DE
Wolfgang Staehle · Ingelheim am Rhein, DE

Key dates

Filing date	Jul 30, 2014
Grant date	Sep 27, 2016
Priority date	—
Expiry date	Jul 30, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to piperidine and pyrazine derivatives according to formulae (Ia), (Ib) and (II) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.