Crystal structures of SGLT2 inhibitors and processes for preparing same

US9453039B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Jack Z. Gougoutas · Princeton, US
• Hildegard Lobinger · Princeton, US
• Srividya Ramakrishnan · Hyderabad, IN
• Prashant P. Deshpande · Princeton, US
• Jeffrey T. Bien · Princeton, US
• Chiajen Lai · Livermore, US
• Chenchi Wang · Princeton, US
• Peter Riebel · Kaiseraugst, CH
• John A. Grosso · Princeton, US
• Alexandra A. Nirschl · Yardley, US
• Janak Singh · Lawrenceville, US
• John D. DiMarco · East Brunswick Township, US

Key dates

• Filing date: Jul 10, 2013
• Grant date: Sep 27, 2016
• Expiry date: Apr 28, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H7/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to physical crystal structures of a compound of the formula I:wherein R1, R2, R2a, R3 and R4 are as defined herein, especiallypharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.