Cyclosporin derivatives

US9453051B2 · kind B2 · utility

Assignees

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US
• Lead Discovery Center GmbH · DE

Inventors

• Gunter Fischer · Hamburg, DE
• Miroslav Malesevic · Bodenwerder, DE
• Frank Erdmann · Bodenwerder, DE
• Jan Kühling · Bodenwerder, DE
• Michael Bukrinsky · Glenwood Landing, US
• Stephanie Constant · Herndon, US
• Gerd Ruhter · Hamburg, DE
• Peter Nussbaumer · Schwanenstadt, AT
• Klaus Dinkel · Bochum, DE

Key dates

• Filing date: Aug 29, 2012
• Grant date: Sep 27, 2016
• Expiry date: Nov 19, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y502/01008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.