Protection of cells from Alu-RNA-induced degeneration and inhibitors for protecting cells
US9453226B2 · kind B2 · utility
18Cited by
2References
25Claims
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Key dates
| Filing date | Jan 17, 2014 |
| Grant date | Sep 27, 2016 |
| Priority date | — |
| Expiry date | Jan 17, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB of the cell. Administering an inhibitor of MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), can be therapeutically useful in the context of age-related macular degeneration and geographic atrophy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.