Methods for inhibiting tie-2 kinase useful in the treatment of cancer
US9457019B2 · kind B2 · utility
60Cited by
2References
42Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 7, 2014 |
| Grant date | Oct 4, 2016 |
| Priority date | — |
| Expiry date | Nov 7, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravazation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.