Immunomodulating compositions and methods of use thereof

US9457047B2 · kind B2 · utility

Assignees

• Whitehead Institute · US
• Massachusetts Institute of Technology · US
• TRUSTEES OF BOSTON UNIVERSITY · US
• The General Hospital Corporation · US

Inventors

• Ifat Rubin-Bejerano · Belmont, US
• Gerald R. Fink · Sharon, US
• Claudia Abeijon · Worcester, US
• Daniel S. Kohane · Newton, US
• Jason Fuller · Boston, US
• Robert S. Langer · Newton, US

Key dates

• Filing date: Sep 26, 2013
• Grant date: Oct 4, 2016
• Expiry date: Sep 26, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2405/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.