Allograft tolerance induction
US9457052B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Mar 14, 2014 |
| Grant date | Oct 4, 2016 |
| Priority date | — |
| Expiry date | Mar 14, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2035/122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method inducing chimerism and allograft tolerance by co-infusion of stem/progenitor-like cells and donor cells, wherein the donor cells can be bone marrow cells. The method also comprises the conditioning comprising depletion of CD4+ and CD8+ T-cells and administration of low doses of anti-neoplastic drugs. The inventive method comprises an aspect wherein allograft tolerance is induced without systemically suppressing the immune system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.