Methods for inhibiting C5a with C5a peptides coupled or fused to a carrier protein

US9457078B2 · kind B2 · utility

Assignee

• AFFIRIS AG · AT

Inventors

• Guenther Staffler · Wien, AT
• Christine Landlinger · Wien, AT
• Frank Mattner · Wien, AT

Key dates

• Filing date: Dec 21, 2011
• Grant date: Oct 4, 2016
• Expiry date: Jul 24, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/6081
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a vaccine comprising at least one peptide consisting of amino acid sequence LRANISHKDMQLGR (SEQ ID No. 1) or a peptide fragment thereof (SEQ ID No. 2-13) coupled or fused to a carrier protein comprising at least one T cell epitope, wherein said peptide fragment comprises at least 7 amino acid residues and the amino acid sequence KDMQLGR (SEQ ID No: 7) or KDMQLG (SEQ ID No: 23) under the provision that the peptide fragment does not consist of amino acid sequences HKDMQLGR (SEQ ID No: 16) and HKDMQLG (SEQ ID No: 22).