Synthesis and growth regulatory activity of a prototype member of a new family of aminothiol radioprotectors
US9458100B2 · kind B2 · utility
0Cited by
1References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 1, 2013 |
| Grant date | Oct 4, 2016 |
| Priority date | — |
| Expiry date | Aug 1, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/25
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The synthesis, growth inhibition and radioprotective activity of the PrC-210 aminothiol, 3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol, and its polyamine and thiolated polyamine progenitors are reported. All of the molecules significantly inhibited growth of cultured normal human fibroblasts. The combination of an ROS-scavenging thiol group and a positively charged alkyl-amine backbone provided the most radioprotective aminothiol molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.