Quinazolines as potassium ion channel inhibitors

US9458114B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• James A. Johnson · Lawrenceville, US
• John Lloyd · Yardley, US
• Heather Finlay · Skillman, US
• Ji Jiang · Plainsboro, US
• James Neels · Newtown, US
• Naveen Kumar Dhondi · Secunderabad, IN
• Prashantha Gunaga · Savanuru, IN
• Abhisek Banerjee · Narayanpur, IN
• Ashokkumar Adisechan · Navi Mumbai, IN

Key dates

• Filing date: Sep 27, 2013
• Grant date: Oct 4, 2016
• Expiry date: Sep 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula Iwherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.