Bis-acylated hydroxylamine derivatives

US9458127B2 · kind B2 · utility

Assignees

• Cardioxyl Pharmaceuticals, Inc. · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• John P. Toscano · Glen Arm, US
• Art Daniels Sutton, Jr. · Mount Pleasant, US
• Vincent Jacob Kalish · Annapolis, US
• Frederick Arthur Brookfield · Woodstock, GB
• Stephen Martin Courtney · Woodstock, GB
• Lisa Marie Frost · Abingdon, GB

Key dates

• Filing date: Mar 24, 2015
• Grant date: Oct 4, 2016
• Expiry date: Mar 24, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.