Isoquinolines as potassium ion channel inhibitors

US9458133B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Heather Finlay · Skillman, US
• Ashok Kumar Adisechan · Puducherry, IN
• Naveen Kumar Dhondi · Secunderabad, IN
• Prashantha Gunaga · Savanuru, IN
• John Lloyd · Yardley, US
• Srinivasu Pothukanuri · Bengaluru, IN

Key dates

• Filing date: Mar 10, 2014
• Grant date: Oct 4, 2016
• Expiry date: Mar 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I) (I) wherein A, R1, R1a, R3 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.