Cyclic peptide-based NPR-B agonists

US9458198B1 · kind B1 · utility

Assignee

• Shire Orphan Therapies GmbH · DE

Inventors

• Frank Osterkamp · Berlin, DE
• Heiko Hawlisch · Berlin, DE
• Gerd Hummel · Berlin, DE
• Tobias Knaute · Berlin, DE
• Ulf Reimer · Berlin, DE
• Ulrich Reineke · Berlin, DE
• Bernadett Simon · Bonn, DE
• Uwe Richter · Berlin, DE
• Edgar Specker · Berlin, DE
• Markus Woischnik · Berlin, DE
• Mark R. Hellberg · Arlington, US

Key dates

• Filing date: Jun 12, 2013
• Grant date: Oct 4, 2016
• Expiry date: Feb 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/72
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are cyclic, peptide-based novel compounds having NPR-B agonistic activity. Preferred compounds are cyclic peptides containing conventional or non-conventional L- or D-amino acid residues connected to one another via peptide bonds. In some embodiments, provided herein are a cyclic peptide compound with a ring size that is significantly reduced as compared to known NPR-B agonists, such as CNP.