Method for producing intermediates for the production of novel macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof, and uses of said macrocycles

US9458200B2 · kind B2 · utility

Assignees

• GOTTFRIED WILHELM LEIBNIZ UNIVERSITÄT HANNOVER · DE
• MEDIZINISCHE HOCHSCHULE HANNOVER · DE
• Helmholtz-Zentrum Für Infektionsforschung GmbH · DE

Inventors

• Markus Kalesse · Burgdorf, DE
• Nisar Malek · Hannover, DE
• Ronald Frank · Lehre, DE
• Tobias BRODMANN · Hannover, DE
• Leila Bülow · Hannover, DE
• Andreas Rentsch · Bremen, DE
• Anna-Katharina Girbig · Hannover, DE
• Ulrike Eggert · Hannover, DE

Key dates

• Filing date: Jun 23, 2009
• Grant date: Oct 4, 2016
• Expiry date: Aug 17, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.