ANTI-C-MET tandem Fc bispecific antibodies

US9458245B2 · kind B2 · utility

Assignee

• Merrimack Pharmaceuticals, Inc. · US

Inventors

• Brian Harms · Brookline, US
• Neeraj Kohli · Watertown, US
• Alexey A. Lugovskoy · Woburn, US
• Melissa Geddie · Somerville, US
• Eric Krauland · Lebanon, US
• William George ROACH · Lebanon, US
• Stephen SU · Boston, US
• Adnan ABU-YOUSIF · Boston, US

Key dates

• Filing date: Mar 6, 2014
• Grant date: Oct 4, 2016
• Expiry date: Mar 30, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are tandem Fcs and tandem Fc antibodies (“TFcAs”), e.g., tandem Fc bispecific antibodies (“TFcBAs”), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs bind to the cell surface receptors c-Met and EpCam and inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.