Method for purifying polyethylene glycol having one amino group
US9458292B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 24, 2014 |
| Grant date | Oct 4, 2016 |
| Priority date | — |
| Expiry date | Mar 24, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G65/333
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
A method for purifying a polyethylene glycol compound having one amino group, which includes (A) preparing an aqueous solution of the compound having a pH of 1 to 5, (B) an extracting step of mixing the aqueous solution with a mixed organic solvent to cause layer separation into organic and aqueous layers, wherein a ratio of an organic solvent I is 25 to 65% by mass and a ratio of an organic solvent II is 75 to 35% by mass, the organic solvent I is selected from an aromatic hydrocarbon and an ester, the organic solvent II is a halogenated hydrocarbon, and a mixing ratio Y of I to II, temperature T (° C.) at mixing, and molecular weight M of the compound satisfy the following relationship:1.9×10−6M+0.09≦Y−0.015T≦−1.4×10−6M+0.44and (C) recovering the compound from the aqueous layer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.