Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto
US9458458B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Sep 2, 2014 |
| Grant date | Oct 4, 2016 |
| Priority date | — |
| Expiry date | Sep 2, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3515
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of miR324 or miR324-5p, e.g., the use of nucleobase polymers for antisense disruptions or RNA interference of miR-324 expression or for miR324-5p binding in order to increase Kv4.2 expression. In certain embodiments, the disclosure relates to methods of treating or preventing a neurological disease or condition comprising administering an effective amount of an inhibitor to a subject in need thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.