Patent · US Active

Modified gram positive bacteria and uses thereof

US9458467B2 · kind B2 · utility

0Cited by

2References

25Claims

0Family size

Assignee

INTREXON ACTOBIOTICS N.V. · BE

Inventors

Lothar Steidler · Lokeren, BE
Karolien Van Huynegem · Asper, BE
Klaas Vandenbroucke · Zevergem, BE

Key dates

Filing date	Sep 21, 2012
Grant date	Oct 4, 2016
Priority date	—
Expiry date	Sep 21, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/86
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.