Apparatus for selective excitation of microparticles
US9458501B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 5, 2014 |
| Grant date | Oct 4, 2016 |
| Priority date | — |
| Expiry date | Aug 16, 2034 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L7/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an interference pattern generation module that splits a first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.