Dissolution of amyloid fibrils by flavonoids and other compounds
US9463195B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Dec 14, 2007 |
| Grant date | Oct 11, 2016 |
| Priority date | — |
| Expiry date | Feb 3, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for disrupting amyloid fibrils in a subject, comprising combining an effective amount of a β-2 microglobulin fibril disrupting compound with a medium associated with the subject, are disclosed. The invention also relates to combining the β-2 microglobulin fibril disrupting compound ex vivo with the blood during dialysis treatment of an animal. It also relates to methods for determining which compounds are effective at disrupting amyloid fibrils in a medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.