Patent · US Active

Cell-penetrating oligonucleotides

US9463200B2 · kind B2 · utility

0Cited by

2References

15Claims

0Family size

Assignee

OLIGOMER SCIENCES AB · SE

Inventors

Roger Strömberg · Huddinge, SE
Dmytro Honcharenko · Stockholm, SE
Stefan Milton · Karlskrona, SE

Key dates

Filing date	Feb 28, 2014
Grant date	Oct 11, 2016
Priority date	—
Expiry date	Feb 28, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to modified oligonucleotides of 5-50 nucleotide residues, wherein at least 25% of the nucleotides are independently modified at the 2′ position to comprise the structure of formula (I), wherein base is a purine or pyrimidine moiety; and R1, R2, R3, R4, p and q are as defined in the description. The modified oligonucleotides comprising said structures are useful as medicaments for enhancement of drug uptake in oligonucleotide based therapy in humans and animals.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.