Patent · US Active

Modified protozoan expressing at least two variable surface proteins (VSP), a vaccine comprising it and procedures, uses, and methods thereof

US9463229B2 · kind B2 · utility

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8Claims

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Assignee

UNIVERSIDAD CATOLICA DE CORCOBA (UCC) · AR

Inventor

Hugo Lujan · San Pedro, AR

Key dates

Filing date	Dec 2, 2009
Grant date	Oct 11, 2016
Priority date	—
Expiry date	May 25, 2032

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.