Benzamide derivatives

US9464059B2 · kind B2 · utility

Assignee

• The Translational Genomics Research Institute · US

Inventors

• Tong Wang · Scottsdale, US
• Stephen Gately · Palatine, US

Key dates

• Filing date: Jun 8, 2015
• Grant date: Oct 11, 2016
• Expiry date: Jun 8, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are benzamide derivatives having the formulawherein X is selected from the group consisting of H, halo, —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle, wherein the —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle may be unsubstituted or substituted; Y is selected from the group consisting of H, —C1-C6 alkyl, and —C3-C7 cycloalkyl, the —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle may be unsubstituted or substituted; Z is selected from the group consisting of —NHOH and phenylene diamine group (II) of structureand wherein Q is selected from the group consisting of H, F and Cl. These benzamide derivatives are useful in slowing the expansion of cancer cells.