Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators

US9464082B2 · kind B2 · utility

Assignees

• Abb Vie Inc. · US
• REATA PHARMACEUTICALS HOLDINGS, LLC · US

Inventors

• Pamela L. Donner · Mundelein, US
• Rolf Wagner · Antioch, US
• Jason P. Shanley · Chicago, US
• Howard R. Heyman · Deerfield, US
• Allan C. Krueger · Gurnee, US
• Hui-Ju Chen · Grayslake, US
• Michael J. Rozema · Kenosha, US
• David J. Grampovnik · Waukegan, US
• Melean Visnick · Irving, US
• Eric Anderson · Cleveland, US
• Xin Jiang · Coppell, US
• Christopher F. Bender · Garland, US
• Gary L. Bolton · Ann Arbor, US
• Bradley W. Caprathe · Redford, US
• Chitase Lee · Ann Arbor, US
• William H. Roark · Ann Arbor, US

Key dates

• Filing date: Jan 23, 2015
• Grant date: Oct 11, 2016
• Expiry date: Jan 23, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application relates to: (a) compounds of Formula (I):and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.