Active-electrode integrated biosensor array and methods for use thereof
US9465002B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 2013 |
| Grant date | Oct 11, 2016 |
| Priority date | — |
| Expiry date | Mar 4, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/3276
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.