Compositions comprising TL1A-Ig fusion protein for the regulation of T regulatory cells, and methods for their use

US9468677B2 · kind B2 · utility

Assignee

• The University of Miami · US

Inventors

• Eckhard R. Podack · Coconut Grove, US
• Taylor SCHREIBER · Durham, US
• Samia Q. Khan · Miami, US

Key dates

• Filing date: Feb 20, 2014
• Grant date: Oct 18, 2016
• Expiry date: Mar 5, 2034

Classification

• Technology area (CPC —): General

Abstract

Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also described are combination therapies that include the administration of a TNFRSF25 agonist and an interleukin (e.g., IL-2) and/or an mTOR inhibitor (e.g., rapamycin).