Synthesis of pyrrolidine compounds

US9469609B2 · kind B2 · utility

Assignee

• Zealand Pharma A/S · DK

Inventors

• Asaf Alimardanov · Nanuet, US
• Lalitha Krishnan · Airmont, US
• Maotang Zhou · Cedar Knolls, US
• Ting-Zhong Wang · Pomona, US
• Jianxin Ren · Nanuet, US
• John Leo Considine · Bound Brook, US
• Charles C. Wu · North Wales, US
• Jason Brazzillo · Whitehall Corners, US
• Panolil Raveendranath · Rochester, US
• Karen Sutherland · New City, US
• Mahmoud Mirmehrabi · Halifax, CA
• Subodh Deshmukh · White Plains, US

Key dates

• Filing date: Dec 16, 2014
• Grant date: Oct 18, 2016
• Expiry date: Dec 16, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P39/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.