6-substituted-3H-1,3-benzothiazol-2-one compounds as TARP-gamma 8 dependent AMPA receptor antagonists

US9469632B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Kevin Matthew Gardinier · Fishers, US
• Douglas Linn GERNERT · Indianapolis, US
• Patric James Hahn · Indianapolis, US
• Sean Patrick Hollinshead · Durham, US
• Albert Khilevich · Glenview, US
• Daniel Ray Mayhugh · Carmel, US
• Paul Leslie Ornstein · Carmel, US
• Warren J. Porter · Indianapolis, US
• Jon K. Reel · Carmel, US
• Jeffrey Michael Schkeryantz · Fishers, US
• Patrick Gianpietro Spinazze · Avon, US
• Freddie Craig Stevens · Indianapolis, US
• Jeffrey M. Witkin · New York, US

Key dates

• Filing date: May 21, 2015
• Grant date: Oct 18, 2016
• Expiry date: May 21, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A TARP γ8 dependant AMPA receptor antagonist of the formula:wherein X is CH or N;A isandR1 is as defined herein;its pharmaceutically acceptable salts, uses, and methods for its preparation are described.