Processes for the preparation of pyrrolidine intermediates
US9469633B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 28, 2012 |
| Grant date | Oct 18, 2016 |
| Priority date | — |
| Expiry date | Sep 28, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to processes for the enantio-selective preparation of spyrrolidine derivatives useful in the manufacture of pesticidally active compounds, as well as to intermediates in the processes. The processes include those comprising(a-i) reacting a compound of formula IawhereinP is alkyl, aryl or heteroaryl, each optionally substituted, wherein the heteroaryl is connected at P via a ring carbon atom;R1 is chlorodifluoromethyl or trifluoromethyl;R2 is aryl or heteroaryl, each optionally substituted;with a source of cyanide in the presence a chiral catalyst to give a compound of formula IIawherein P, R1 and R2 are as defined for the compound of formula Ia; and(a-ii) oxidizing the compound of formula IIa with a peroxy acid, or peroxide in the presence of an acid to give a compound of formula VIwherein R1 and R2 are as defined for the compound of formula Ia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.