Chromatographic interface

US9470664B2 · kind B2 · utility

Assignee

• Waters Technologies Corporation · US

Inventors

• Theodore A. Dourdeville · Falmouth, US
• Charles H. Phoebe, Jr. · Uxbridge, US
• Rolf-Rainer Grigat · Halstenbek, DE

Key dates

• Filing date: Jul 11, 2013
• Grant date: Oct 18, 2016
• Expiry date: Mar 12, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/46
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A chromatographic interface for sample handling and manipulation between separations or analyses is provided. The interface has an interfacing unit, a sample acquisition unit, and a sample trapping unit. The sample acquisition unit includes an inflow selector valve, an outflow selector valve, and one or more collection loops. The sample trapping unit includes a trap in fluid communication with the loop and having a stationary phase. The stationary phase can trap an analyte of interest from a fraction of the chromatographic sample separation flow. The tapping unit also has a scavenging gas source and a vacuum source; both can be used to substantially dry the stationary phase.