Methods for the reactivation of latent HIV using cytosine methylation inhibitors and NF-KB activators
US9474788B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Apr 15, 2011 |
| Grant date | Oct 25, 2016 |
| Priority date | — |
| Expiry date | Nov 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16011
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides methods and compositions for reactivating latent immunodeficiency virus in an immunodeficiency virus-infected cell. The methods generally involve contacting an immunodeficiency virus-infected cell with a synergistically effective amount of an inhibitor of cytosine methylation and an NF-κB activator. The present disclosure provides methods and compositions for reducing the reservoir of latent immunodeficiency virus in an individual, and for treating an immunodeficiency virus infection in an individual.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.