Phenylketone carboxylate compounds and pharmaceutical uses thereof

US9475750B2 · kind B2 · utility

Assignee

• PROMETIC BIOSCIENCES INC. · GB

Inventors

• Boulos Zacharie · Keyano, CA
• Christopher Penney · Keyano, CA
• Shaun Abbott · Rue du Bois des Loges, CA
• Lyne Gagnon · Keyano, CA
• Brigitte Grouix · Montréal, CA
• Pierre Laurin · Mount Royal, CA
• Jean-François Bienvenu · Laval, CA

Key dates

• Filing date: Oct 26, 2011
• Grant date: Oct 25, 2016
• Expiry date: Dec 15, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R═C(0); —OC(O)— or —CH(OH)—; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.